| Technical Description |
We have developed a low-costportable reader for thermometric lateral flow immunoassay (TLFIA) using colloidal goldlatex beads as reportersa continuous-wave green laser as the heating source. Instead of using infrared cameras, a single-element infrared sensor is employed for temperature sensing without compromising the sensitivity of the reader. The thermometric assay provides a 10× higher sensitivity than color visualizationthe results are sufficiently quantitative to support decision making in point-of-care testing for infectious diseases (such as COVID-19). |
| Scientific Breakthrough |
\"1. Demonstrate that the quantification accuracy of lateral flow immunoassay is sufficient to support medical decision-making in POCTtelemedicine.2. Develop a low-cost portable TLFIA reader, consisting of a low-power lasera focused single-element infrared sensor as the key components, to realize telemedicine at the level of biochemical detection. 3. Employ an infrared sensor to detect thermal radiation, instead of a charge-coupled device to detect reflected visible light, outperforming similar POCT systems developed by international manufacturers.\" |
| Industrial Applicability |
\"Practicalpotential applications that have been identified for this invention include1. Personal health care at home2. Rapid epidemic detectiontelemedicine in medical institutions3. Reagent developmentanalysis by academicR&D units4. Fooddrug examination by government agencies5. Product developmentmanagement by in vitro diagnostics (IVD) companiesAccording to the report of MarketsandMarkets™, the lateral flow assays market is projected to reach USD 10.2 billion by 2025 from USD 8.2 billion in 2020 at a CAGR of 4.5 during the forecast period.\" |
