| Technical Description |
These stimuli-switchable nanoparticles coated with the cleavable outer polymer coatingmultifunctional peptides may afford a new platform for anticancer drugmiR. These nanoparticles possess characteristics of environmental response, active targeting,gene/chemo combinatorial therapeutics, thus providing spatiotemporal control of posttranｓｃｒｉｐｔional gene regulation, smart nuclear/mitochondrial localization,simultaneous inhibition of multiple progression pathways of tumor cells for enhancing antitumor efficacysafety of cancer therapy. |
| Scientific Breakthrough |
Two characteristics:(1) The advantage of using pH-sensitive imine bond: The coating of nanoparticles has a long-chain PEG derivative with acid-sensitive imine bond, thus protecting the targeting peptides from degradation in the blood circulation. The imine bond can be hydrolyzeddetached to expose the targeting/penetrating peptides.(2) The specificity of the peptide sequence: These peptides can target surface receptors of cancers to increase tumor penetration. The targeting peptides may promote localization into the nucleusmitochondria of cancer cells to trigger cell apoptosis. |
| Industrial Applicability |
This combination has the following industrial application potential: These three peptides can not only promote the target of nanoparticle to colorectal cancer, pancreatic cancer,headneck cancer, but also increase the penetration of chemo-gene therapeutics into cancer cells. They may further target the nucleusmitochondria to induce cancer cell apoptosis. In colorectal cancer-headneck cancer-bearing mice, our formulations display better anti-tumor effectlower (or the same) toxicity to non-tumor tissues than those of Onivyde. |
