• Technical Name
  • Heterocyclic compounds and use thereof
  • Operator
  • National Health Research Institutes
  • Booth
  • Precision Health Ecosystem
  • Contact
  • 陳萲蓉
  • Email
  • enachen@nhri.edu.tw
Technical Description In this technology, a series of potent MOR/NOP agonists has been developed, which demonstrated potent antinociception in tail flick and cancer pain mouse models with fewer side-effects in respiratory suppression, heart rate decreasing, and constipation models than morphine.
Scientific Breakthrough 1. A first-in-calss pain-killer with low adverse-effects.2. A MOR/NOP dual and biased-agonist, which possesses a new mode-of-action.3. A series of patentable small molecules with novel structural scaffold.
Industrial Applicability A fast painkiller -The onset time of this drug is within ten minutes after subcutaneous injection.Low addiction -The NOP activation of this drug reduces addiction.Slight affecting in the digestive system - This drug did not cause constipation.High level of safety -This drug caused low and short-term effects on lung and heart function.