Traumatic brain injury (TBI) is difficult to treat due to the blood-brain barrier and limited drug delivery. We developed a hydrogel-based system combining miR-6236 sponge DNA, cationic polymers, and magnetic field responsiveness. This platform protects DNA, enhances cellular uptake, and enables localized delivery. In animal models, it reduced inflammation, promoted neural repair, and improved recovery—offering a promising, targeted approach for TBI and other neurological conditions.

We developed a conductive hydrogel-based gene delivery platform that efficiently targets the brain, enabling neural cell transfection and inflammation modulation in TBI models. This versatile system delivers various nucleic acid drugs and shows strong potential for treating TBI and other CNS disorders like stroke, Alzheimer＇s, and spinal cord injury.

TBI lacks effective treatments despite its global impact. We developed a conductive hydrogel-based gene delivery platform enabling targeted brain delivery and neural regeneration. This versatile system shows strong potential for TBI and other CNS disorders like stroke and Alzheimer’s, addressing critical needs in a multi-billion-dollar neuroregenerative medicine market.