Coherent Raman system driven by a single supercontinuum laser source offers some grand advantages, such as complete coverage of the Raman-active region for observing various types of molecules, independent wavelength adjustment of more than two laser beams for upgraded sensitivityspecificity. This technique is aimed to observe neuronal responsesmolecular dynamics in an attempt to decipher the complex working mechanisms of the brain.

Our team proposes a multiple-plate white-light laser source, covering an octave-spanning spectral range. The energy density is increased by 4-5 orders of magnitude, reaching hundreds of nJ/nm, making it suitable for applications in coherent Raman material detectionbiomedical imaging. Our technique has been applied in the biological imaging of Drosophila brainsdemonstrated Raman signal enhancement by a factor of 100.

Single ultra-broadband laser source can be utilized in material spectroscopic detection. In combination with coherent Raman spectro-microscopy, it enables access to the entire Raman-active region in applications such as pathological screening of cancerous tissues, drug delivery,deciphering of memory formationcircadian rhythms.