Technical Name Stem Cell Sheets for Cerebral Neurovascular Reconstruction
Project Operator National Defense Medical Center
Project Host 周中興
Summary
We first construct the cell sheet composed of human neural stem cells, endothelial cellsextracellular matrix, which are committed to generating neurovascular networks. Such novel building blocks have been applied to surgical brain traumaspinal nerve injuries. Improvements in neurological assessmentshistological evidence of regenerating functional neurovascular tissue have been demonstrated in animal models. We are applying these novel techniques to spinal cord injurystroke.
Scientific Breakthrough
"Compared with other technologies of cell transplantation treating brain injury, we have innovated cell sheet transplantation technology: 
(1) Directly targeting the lesions for transplantation, not via peripheral blood circulation, avoiding the influence of the blood-brain barrier
(2) Cell sheet transplantation avoids damage to brain tissue caused by acupuncture when injecting cells
(3) Extrace
Industrial Applicability
"1. Medical industry – brain tissue regeneration, transplanted cell layer to reconstruct neurovascular tissue to treat patients with stroke, degenerative brain disease, brain trauma, spinal cord injury, diabetic footother vascularneurological disorders.
2. Biomedical materials – manufacturing of cell sheets, bio-materials for tissue engineering for reconstructing the neurovascular tissue.
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