Technical Name An interpenetrating pore structure bone substitute and use thereof
Project Operator Kaohsiung medical university
Project Host
Summary
The new three dimensional scaffold provides a novel strategy to guide alveolar bone regeneration. This scaffold can be made by three-dimension printer with thermo-response hydrogel in order to fit individual alveolar bone defects. Furthermore, the biomaterials scaffold can combine with rebuilt alveolar bone shapes and insertion of dental implant at the same time to solve the quality and quantity of alveolar bone as well as the improperly length ratio between tooth crown and implant fixtures and a heavy occlusal force.
Scientific Breakthrough
(1)溫感水膠在溫度上升時會有收縮的能力,讓燒結粉體能構緻密化,其原理猶如粉末冷均壓(cold isostatic pressing;CIP)成型技術,可均勻收縮,減低收縮時內應力,故不需經緩慢耗時收乾過程,可立即進行燒結過程,且得到不龜裂地燒結體與較佳機械性質。
(2) 溫感水膠的黏性可以經均勻攪拌氣孔入泥狀胚體,經燒結後可留下孔洞,也可真空攪拌除氣以利3D列印,成為3D列印墨水材料,進行複雜形狀與互穿性孔洞的基層列印產品。
(3) 讓引導骨生成手術及植牙手術同時一次完成之外,亦可精確預測骨生成的高度及形狀。即利用電腦斷層掃描後,取得3D影像,轉成可列印的3D圖檔後進行可吸收式生物陶瓷列印成生胚,經高溫燒結獲得尺寸外型與臨床應用上相符,並且具有互穿性孔洞與良好機械強度。
Industrial Applicability
本發明係將具溫感性水膠/陶瓷材料,透過3D列印技術成型技術製作成型。用於植入性陶瓷醫材較傳統翻膜製作的方式有較精準型態且可有效設計互穿性孔洞,其收縮平均可保留型態不易變型,也較雷射陶瓷3D列印技術成本來的低且不會有熱震的效應。
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