| Technical Name | 早期非小細胞肺癌組織內腫瘤浸潤白血球的免疫特性分析。 | ||
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| Project Operator | National Taiwan University Centers of GenomicPrecision Medicine | ||
| Project Host | 楊志新 | ||
| Summary | In the current of study, cell subsets, cell proportionsthe immune function of tumors-infiltrating leukocytes were used to indicate the features of tumor immune microenvironment in non-small cell lung cancers (NSCLCs) with different type of EGFR genetic alteration. |
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| Scientific Breakthrough | Previous, Guo Xinyi et al. revealed pre-exhausted T cellsexhausted T cells detected in patients with NSCLCs. In the current of study, we found the subsetthe proportion of tumors-infiltrating exhausted T cells were varied with types of EGFR genetic alteration in patients with non-small cell lung cancers (NSCLCs). |
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| Industrial Applicability | Combining multicolor flow cytometry to detect cell subsets, cell proportions, immune function of tumors-infiltrating leukocytesEGFR genetic typing to explore a set of cellular biomarkerstheir corresponding molecular signatures for improving the efficacy of therapeutic strategies in treating non-small cell lung cancers (NSCLCs) patients with different types of EGFR genetic alteration. |
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| Matching Needs | 天使投資人、策略合作夥伴 |
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| Keyword | precision medicine multicolor flow cytometry EGFR genetic typing tumors-infiltrating leukocytes exhausted T cells EGFR genetic alteration biomarker tumor immune microenvironment non-small cell lung cancers (NSCLCs) immunotherapy | ||
| Notes | |||
- Contact
- yslee@ntu.edu.tw
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