Our PEDD has been used to detect the HNE level in both tearwound fluids of 9 patients,the limitations of detection were about 0.76 μg/mL0.63 μg/mL respectively. Our device requires only 15 minutes, 3 μL of clinical sample for each test,offers superior sensitivity compared to other current HNE detection methods. The HNE concentrations in the patient samples have shown that the elevated HNE levels might suggest an abnormal healing of either acutechronic wounds, consistent with previous studies that showed excess protease levels in all non-healing wounds.

Above table compared our PEDD with other HNE detection methodsPOC devices for wound assessment.

In conclusion, our PEDD provides potentially valuable insights on the relationships between wound statusHNE level. In the near future, we hope that our approach may be used to develop PEDD assays using different substratestargeting additional biomarkers for clinical wound assessment as well as for the investigation of additional disease states.

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