The lung simulation system has breathing mechanism to the human lung, thereby improving the inaccuracy of animal testing results during the development of the inhaled drugs, providing the effective information before the human clinical trials, and improving the inhaler design to achieve more accurate drug delivery. By combining a structure similar to the human lungs and a human breathing mechanism, the human lungs can be effectively simulated, so that the information related to the human body can be obtained with a higher reliability. Finally, this invention provides a system and method for simulating the deposition of substances in the lungs of the human body, by which the absorption and distribution of the substances in the human lungs can be observed. It can apply to multiple applications, including the study of inhaled drugs, air pollution research, cigarette filter research and virus infection research.

This innovative lung organ model is the only device that integrates breathing mechanism and bronchial structure in the current verification approach for the inhalation drug. When the lung organ model with different breathing conditions is established, the aerosols generated by the nebulizer can enter the lung organ model through the breathing mechanism, which can simulate the aerosols entering into the deep lung due to impaction or diffusion, and accumulating in the branched structure of the lungs and even in the alveoli.

The human lung simulation system can be used for the development and research of inhaled drugs to cure the lung diseases such as pneumonia and lung cancer, the monitoring of airborne particles and air pollutants, the development of e-cigarette, the selection of cigarette filters, and the prevention of virus infection.