The invention of sub-nanometer gold administration can inactivate the endotoxin activity and diminish the inflammatory by via blocking the activate sites (i.e., lipid A) of lipopolysaccharide, a bioactive bacterial debris for causing wound inflammation. In vitro and in vivo studies show that our specific gold nanocluster can reduce the cytokine secretions and improve infected wound repair.

This invention of gold sub-nanoclusters based on molecular design can effectively compact the intramolecular long hydrocarbon chain-chain distance of lipid A, thus, reduce the inflammation caused by the binding between endotoxin and TLR 4. Therefore, the gold sub-nanoclusters can diminish the immune response elicited from endotoxin, and be used in biomedical and preventive medicine applications.

This nanogold sticker demonstrated that this technology based on gold sub-nanoclusters could be used as an endotoxin-inhibiting material to decrease pro-informatory factors. The invention might provide opportunities for the healthcare of aging society, which might prevent the problem of antibiotic resistance getting worse and reduce the medical expenses of chronic wounds.