Technical Name Dengue and Zika virus domain III-flagellin fusion and glycan-masking E antigen for prime-boost vaccine design
Project Operator 生物科技所
Project Host 吳夙欽
Summary
Provided is a prime-boost vaccination includes the second-dose booster of four DENV serotype and ZIKV FliC-DIII proteins to enhance the virus-neutralizing antibody titers. The invention also includes the ZIKV E protein ij loop (E-248NHT) mutation by glycan masking to reduce the elicitation of cross-reactive antibodies for DENV and ZIKV infection enhancements.
Scientific Breakthrough
Provided is a prime-boost vaccination includes the second-dose booster of four DENV serotype and ZIKV FliC-DIII proteins to enhance the virus-neutralizing antibody titers. The invention also includes the ZIKV E protein ij loop (E-248NHT) mutation by glycan masking to reduce the elicitation of cross-reactive antibodies for DENV and ZIKV infection enhancements.
Industrial Applicability
Our invention provides a prime-boost vaccine design including the second-dose booster of four DENV serotype and ZIKV FliC-DIII proteins to enhance the virus-neutralizing antibody titers and protection. Our invention also includes the ZIKV E protein ij loop (E-248NHT) mutation by glycan masking to reduce the elicitation of cross-reactive antibodies for DENV and ZIKV infection enhancements.
Keyword dengue virus four seotypes Zika virus vaccine flagellin E domain III prime boost immunization glycan masking cross reactive antibodies vaccine design
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