| Technical Name | Utilization of CRISPR gene editing technologyadeno-associated viral vectors to develop humanized disease mouse models | ||
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| Project Operator | Department of Clinical Laboratory SciencesMedical Biotechnology, College of Medicine, National Taiwan University (A | ||
| Project Host | - | ||
| Summary | Humanized mouse models have been developed to replace nonhuman primates as preclinical testing modelsbridge ex vivo to in vivo. Our team has applied CRISPR/Cas9 technology in generation of genome-modified mice in the immunodeficient NOD/SCID-IL2rγnull (NSG) genetic background used for generating humanized mice. The sgRNAs targeting b2mFVIII genesthe CRISPR/Cas 9 RNA were microinject |
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| Scientific Breakthrough | - |
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| Industrial Applicability | - |
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| Keyword | __ __ | ||
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