Planar microfluidics has played an important platform for novel medical materials for decades, but the medical articles pointed out that the experiment results generated from the planar microfluidics are very different from the clinical trials. Hence the aim of this research is to develop a novel fabrication process to create a truly 3D microfluidic for state-of-the-art medical researches.

A 3D printed ABS moldPDMS casting were conducted to create a 3Dfully transparent microfluidic device. In the fabrication process, solvent evaporation step was used to minimize the surface roughness of a printed mold for creating a fully transparent microfluidic chip while a two-step dissolution process was used to completely dissolve the embeddedslender ABS inside the PDMS chip.

The fully transparent3D microfluidic chip could be applied in medical research industries, such as (1) microfluidic multi-bifurcation chip could be used to study the medicine transportation phenomenon in the vessels of the lung (2) the research related to an aneurysm inside the brain (3) fabricating complicated microvessel system for cell culturing, blood analysis,artificial organ.