The photo-induced thrombosis organ-on-a-chip system integrates microfluidic chip technology with a vascular-mimetic microcirculation module. Laser or LED irradiation enables precise control of vascular endothelial injury location and extent, reproducing thrombus formation with real-time analysis of platelet dynamics. Combined with in vivo animal models, this platform establishes an integrated in vitro–in vivo validation strategy to accelerate anti-thrombotic drug screening and translational development.

The photo-induced thrombosis organ-on-a-chip system establishes an innovative biomimetic model for vascular thromboembolic diseases. By precisely inducing endothelial injury through light stimulation, the platform recapitulates thrombus formation and platelet dynamics under microcirculatory conditions. With controllable and real-time visualization of thrombotic processes, combined with in vivo validation models, it provides a next-generation translational platform for disease mechanism studies, anti-thrombotic drug screening, and therapeutic development.

In response to the needs of cardiovascular and cerebrovascular disease management and precision medicine in Taiwan, the photo-induced thrombosis organ-on-a-chip system provides a high-efficiency and reproducible in vitro platform for thrombotic disease evaluation. It supports preclinical assessment of anti-thrombotic drugs, novel therapies, and biomaterials, reducing animal study costs and accelerating drug development and translational biomedical applications.