• Technical Name
  • 循環腫瘤細胞預濃縮晶片
  • Operator
  • National Yang Ming Chiao Tung University
  • Booth
  • 精準健康(醫材&防疫科技) Precision Health(Medical Device & Pandemic Prevention)
  • Contact
  • 李博仁
  • Email
  • liborran@nycu.edu.tw
Technical Description We designed a cascade spiral microfluidic device (i-Finity®)continuously isolated the unlabeled cancer cells from blood samples without lysing processes. The results showed that the i-Finity® device excluded a high percentage of RBCs in the first stagerecollected the cancer cells in the second stage. The i-Finity® device can efficiently enrich the cancer cells more than 1000 times in 10 minutes, which substantially curtailed sample preparation timeimproved the accuracy of diagnosis.
Scientific Breakthrough To optimize particle focusing conditions in the cascaded platform, two-stage spiral microchannels are designed with different heights. This allows the i-Finity® system to operate at high efficiency, removing 99.99 of red blood cells without antibody labeling. In addition, it can also collect over 80 of cancer cells effectively under a flow rate over 1 mL/min. In conclusion, this device provides a fast, high-throughput, low-cost,preconcentration platform for cancer cell detection technologies.
Industrial Applicability We designed a cascade spiral microfluidic device (i-Finity®)continuously isolated the unlabeled cancer cells from blood samples without lysing processes. The results showed that the i-Finity® device excluded a high percentage of RBCs in the first stagerecollected the cancer cells in the second stage. The i-Finity® device can efficiently enrich the cancer cells more than 1000 times in 10 minutes, which substantially curtailed sample preparation timeimproved the accuracy of diagnosis.
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