Technical Name 水溶液蛋白質與藥物微脂體檢測上的奇兵 - 生物結構小角度X光散射
Project Operator National Synchrotron Radiation Research Center
Project Host 鄭有舜
Summary
1.High flux mode for integrated measurements of SAXS/WAXS/UV-Vis-absorption/Refractive-index/Multi-angle-light-scattering (MALS) with an online high-performance liquid chromatography (HPLC) instrument, suitable for exploring biomacromolecular solution structures of a wide length scalestructural kinetics down to microsecond time scale.
2.Ultra SAXS (USAXS) mode for resolving hierarchical structures of bio-machinery assembly up to a few m length scale.
3.Anomalous SAXS mode for metalmineral distributions (including calcium) in bio organelledrug carriers.
Scientific Breakthrough
1.high flux mode for integrated measurements of SAXS/WAXS/UV-Vis-absorption/Refractive-index/Multi-angle-light-scattering with an online high-performance liquid chromatography instrument, suitable for exploring biomacromolecular solution structures of a wide length scalestructural kinetics down to microsecond time scale.
2.Ultra SAXS mode for resolving hierarchical structures of bio-machinery assembly up to a few um length scale.
3.Microbeam SAXS/WAXS mode for structural mapping of the texturesspecific infected cells in natural/synthetic bio-tissues, organelles,biomaterials.
Industrial Applicability
1.Fast structural screening process for biomolecules with molecular mass from 1 kDa to 10 MDa.
2.Allergenallergic-reaction-induced structural changes.
3.Interaction between metallic nanoparticleslipid moleculesits connection to inflammation inhibition.
4.Protein misfoldingaggregation in Alzheimer‘sother RAN/DNA related diseases.
5.Structuralcompositional analysis of combined antiretroviral (ARV) drugs used in ARV therapy.
6.Other cancer-related studies like solution-based structural analysis of phosphatasesglycoprotein.
Matching Needs
天使投資人、策略合作夥伴
Keyword Biological small- and wide-angle X-ray scattering Fast structural screening process Allergic-reaction-induced structural changes Metallic nanoparticles and lipid molecules Protein misfolding and aggregation RAN/DNA related complexes Diary products in solution, gel, or solid forms Intrinsically disordered proteins
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