Technical Name Pyrazolylquinoline derivatives, their preparation processes, and pharmaceutical compositions comprising the same
Project Operator Kaohsiung medical university
Project Host
Infection by dengue virus (DENV) result in serious diseases ranging from acute self-limiting febrile illness to life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). In Taiwan, DENV infection is still a serious sanitary problem. To date our results, we demonstrated that the pyrazolylquinoline derivative compounds exhibited significantly inhibition effect at non-cytotoxicity doses on DENV replication. We used a DENV-infected ICR mouse model to show that pyrazolylquinoline derivative compounds, exerted anti-DENV effects in vivo.
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