Technical Name A novel polysaccharide from fermented Phellinus linteus provides adjuvant chemotherapy in lung cancer and alleviates drug-induced pulmonary fibrosis.
Project Operator Southern Taiwan University of Science and Technology
Project Host
Summary
The present invention combines Phellinus linteus extract and anti-cancer drug BLM to ensure that the Phellinus linteus extract can effectively inhibit free radicals to inhibit pulmonary fibrosis. Phellinus linteus after the extraction of the antioxidant capacity of the evaluation test; and then mouse lung cancer cells LL2 and human lung cancer cell A549 cultured 72 hours to observe the cytotoxicity test; Finally, by animal experiments to explore Bleomycin induced lung Fibrosis of the incidence of treatment and prevention of the effectiveness. After careful treatment of pomegranate can not only increase the body's absorption rate, the experiment confirmed that the composite composition does have the effect of adjuvant therapy, by the mulberry extract compound Western medicine BLM drug use, has a more significant effect than the Western medicine, Can also reduce the incidence of side effects of pulmonary fibrosis, and to provide mutual assistance between the various drugs for Taiwan suffering from pulmonary fibrosis in patients with the Gospel.
Scientific Breakthrough
本發明將桑黃萃取物以及抗癌藥物BLM合併,為確保該桑黃萃取物能夠有效的抑制自由基,以抑制肺部纖維化。桑黃經過細微化後進行萃取後,作抗氧化能力的評估試驗;再以小鼠肺癌細胞LL2和人類肺癌細胞A549培養72小時,觀測其細胞毒性試驗;最後,藉由動物實驗探討Bleomycin誘導肺部纖維化的發病率方面的治療及預防的功效。經過細微化處理的桑黃不僅可增加人體吸收率,經實驗所證該複合組成物確實具有輔助治療之效果,藉由將桑黃萃取物複合西藥BLM藥物使用,有著比西藥更顯著的效果,亦能降低副作用肺纖維化的發生,並提供各藥物間的相互輔助運用,為台灣罹患肺部纖維化之患者帶來福音。
Industrial Applicability
本發明將桑黃萃取物以及抗癌藥物BLM合併,為確保該桑黃萃取物能夠有效的抑制自由基,以抑制肺部纖維化。桑黃經過細微化後進行萃取後,作抗氧化能力的評估試驗;再以小鼠肺癌細胞LL2和人類肺癌細胞A549培養72小時,觀測其細胞毒性試驗;最後,藉由動物實驗探討Bleomycin誘導肺部纖維化的發病率方面的治療及預防的功效。經過細微化處理的桑黃不僅可增加人體吸收率,經實驗所證該複合組成物確實具有輔助治療之效果,藉由將桑黃萃取物複合西藥BLM藥物使用,有著比西藥更顯著的效果,亦能降低副作用肺纖維化的發生,並提供各藥物間的相互輔助運用,為台灣罹患肺部纖維化之患者帶來福音。
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