Monoglycosylated spike protein vaccine provides better protection against infections of SARS-CoV-2its variants of concern. Spike protein, which is the main immunogen in all current vaccines, is heavily glycosylatedthe epitopes covered by glycans are usually less immunogenic. Monoglycosylated spike protein vaccine, when vaccinated, can elicit better immune response with a more complete protection against all possible epitopes from spike polypeptide sequence,provide better protection against infections from variants of concerns.

This successful technology is the digital interventions on depression patients based on (1) heart rate variability bio-feedbacks (HRVBs) measured by a novel flexible sensor patch attached on patient’s wrist(2) an APP. An innovative flexible low-power PPG patch has been designed which is capable of providing weeks of high-quality PPG signals which are essential towards accurate estimation of HRV for favorable efficacy of designed digital interventions. Also, An AI model correlating the HRVsand PHQ-9/HDRS scores of depression patients will be built based on collected data.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected human cell through ACE2. This study is developing a Pd nano-thin film electrode for electrochemical impedance spectroscopy. This invention can quantify neutralize antibody too. The detection platform can be used to screen 1 microliter anti-virus infection drug sample within 21 mins. Compare to SPR standard, our invention only needs 1/10000 concentration of ACE2reaction volume is ~1/30 than SPR. This invention can be adapted in detection of cancer markers,other emergency infection diseasestherapeutic drugs, too.

The interpretation of next generation sequencing is a big challenge. In order to improve the molecular diagnosis of the patient, we developed the AI_Variant prioritizer, a machine learning based variant prioterization system that can help to prioritize candidate variants for human disease. This module highlighted the possible disease causing variants to help clinician to increase the disease diagnostic yield and decrease the load of manpower.

We are proposing a pipeline including de novo genome assemblywhole genome SNP array design to improve the practice in precision medicineprecision agriculture. We design GABOLA, a de novo genome assembly system, combining advantages in leading sequencing platform, to construct completeaccurate individual genomes. GABOLA can resolve large structural variants, fills the gap in human reference genome,avoid the bias from reference genome. We combine the knowledge of population geneticsfunctional information to design whole genome SNP array to aid future genomic study.

This technology multiple research to integrates the developed production system of the "smart integrated production system". Using AI to identify pestsdiseases,identify the high temperature resistant varieties,developed Root temperature control system,using IOT to establish Big data. An adopted robot will be used to assist sprayingharvesting in the future.